There is increasing emphasis from funding agencies on transdisciplinary approaches to integrate science and end-users. However, transdisciplinary research can be laborious and costly and knowledge of effective collaborative processes in these endeavors is incomplete. More guidance grounded in actual project experiences is needed. Thus, this article describes and examines the collaborative process of the Ecological Effects of Sea Level Rise in the Northern Gulf of Mexico transdisciplinary research project, including its development, implementation, and evaluation. Reflections, considerations, and lessons learned from firsthand experience are shared, supported with examples, and connected to relevant scholarly literature.