The current report summarizes Great Lakes mussel tissue contaminants of emerging concern (CEC) data obtained between 2013-2015. The study design informs MWP management, stakeholders and general public about the frequency of occurrence, and the magnitude of CECs in mussels. We tested multiple bivalve species and sediment samples for accumulation of flame retardants, stain resistant compounds, pharmaceutical and personal care products, endocrine-disrupting chemicals, and current use pesticides. Our 2014-15 Great Lakes effort was a retrospective analysis of dreissenid (zebra/quagga) mussels from multiple studies in our work under the Great Lakes Restoration Initiative.