As a Federal trust species, the well-being of the striped bass (Morone saxatilis) population along the Eastern Seaboard is of major concern to resource users. Striped bass are an extremely valuable commercial and recreational resource. As a principal piscivore in Chesapeake Bay, striped bass directly or indirectly interact with multiple trophic levels within the ecosystem and are therefore very sensitive to biotic and abiotic ecosystem changes. For reasons that have yet to be defined, the species has a high intrinsic susceptibility to mycobacteriosis. This disease has been impacting Chesapeake Bay striped bass since at least the 1980s as indicated by archived tissue samples. However, it was not until heightened incidences of fish with skin lesions in the Pocomoke River and other tributaries of the Chesapeake Bay were reported in the summer and fall of 1996 and 1997 that a great deal of public and scientific interest was stimulated about concerns for fish disease in the Bay. By 2005, multiple research groups had studied or were independently investigating this disease issue. Identified research redundancies made apparent the need for improved communications, integration of science efforts, and resource optimization. In May of 2006, the U.S. Geological Survey (USGS), Leetown Science Center, partnered with the National Oceanographic and Atmospheric Administration/ National Ocean Service (NOAA/NOS), Cooperative Oxford Laboratory, to sponsor a workshop on mycobacteriosis in Chesapeake Bay striped bass. This workshop involved the principal Federal, State, and academic scientists involved with this issue as well as the resource managers. The goals of this workshop were to: 1. Establish the state of knowledge; 2. Develop a prioritized research agenda; and 3. Identify mechanisms by which research efforts could be optimized.