Publication Details
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Cutaneous Granulomas in Dolphins Caused by Novel Uncultivated Paracoccidioides brasiliensi
Author(s): Vilela, R.; G.D. Bossart; J.A. St. Leger; L.M. Dalton; J.S. Reif; A.M. Schaefer; P.J. McCarthy; P.A. Fair; L. Mendoza
NCCOS Center: CCEHBR
Publication Type: Journal Article
Journal Title: Emerging Infectious Diseases
Date of Publication: 2016
Reference Information: 22(12):
2097-2103
Abstract: The etiology of cutaneous granulomas in dolphins was believed to be Lacazia loboi causing a similar disease in humans. This hypothesis was recently challenged by reports that the DNA sequences from dolphins grouped this pathogen among Paracoccidioides brasiliensis DNA sequences. We conducted phylogenetic analysis on six Tursiops truncatus USA dolphins with cutaneous granulomas and displaying chains of yeast cells in the infected tissues. The evaluated Kex DNA sequences from the six dolphins showed 100% homology to P. brasiliensis, 73% to L. loboi and 62% to P. lutzii, parsimony analysis placed the six dolphin DNA sequences within the human P. brasiliensis strains. This cluster was the sister taxon, to P. lutzii and L. loboi. Our molecular data support previous findings and suggest that a novel uncultivated strain of P. brasiliensis restricted to cutaneous lesions in dolphins, likely is the etiologic agent of the disease termed “lacaziosis/lobomycosis”, herein referred as “paracoccidioidomycosis ceti”.
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